In AD, presenilin‐1 and presenilin‐2, which processes the amyloid precursor protein (APP) to generate amyloid‐β, predominantly localized at the MAM (Area‐Gomez et al, 2009), and up‐regulated MAM proteins were found in the AD brain and APP‐transgenic AD mouse model (Area‐Gomez et al, 2012; Hedskog et al, 2013). Here, APP is linked to Alzheimer disease.