Considering the Sig1R aggregation was also observed in sporadic ALS cases (Prause et al, 2013) and the MAM disruption was similarly observed in VAPB (De Vos et al, 2012)‐, TDP‐43 (Stoica et al, 2014)‐, or FUS (Stoica et al, 2016)‐linked ALS cell models, dysfunction of the MAM might widely be involved in various ALS cases. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.