Therefore, in contrast to ALS studies including ours, over‐activation of MAM function seems to be involved in neurodegeneration in AD, while parkin, DJ‐1, and α‐synuclein, the gene products of inherited PD, are required for neuroprotective function of the MAM and interaction with ER and mitochondria (Paillusson et al, 2016). This evidence concerns the gene SGCG and amyotrophic lateral sclerosis.