SIGMAR1 and amyotrophic lateral sclerosis: For instance, cytotoxicity was induced by overexpression of mutant Sig1R proteins in cultured cells (Tagashira et al, 2014; Gregianin et al, 2016), and elevated expression level of Sig1R in ALS and/or FTLD linked with SIGMAR1 mutation in 3′‐untranslated lesion was reported (Luty et al, 2010).