In contrast to the cited work, our study is the first to point out that Sig1R deficiency clearly induced IP3R3 mislocalization, and the loss of Sig1R–IP3R3 interaction is responsible for the Ca2+ deregulation at the MAM both in Sig1R‐ and SOD1‐linked ALS. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.