In AD, presenilin‐1 and presenilin‐2, which processes the amyloid precursor protein (APP) to generate amyloid‐β, predominantly localized at the MAM (Area‐Gomez et al, 2009), and up‐regulated MAM proteins were found in the AD brain and APP‐transgenic AD mouse model (Area‐Gomez et al, 2012; Hedskog et al, 2013). The gene discussed is SGCG; the disease is Alzheimer disease.