The previous studies showed that Ca2+ flux from ER to mitochondria was important for ATP synthesis in mitochondria (Fujimoto & Hayashi, 2011) and that calpain activated by Ca2+ release into the cytoplasm was involved in ALS‐linked pathological TDP‐43 processing (Yamashita et al, 2012). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.