Paradoxically, these women stand to benefit the most from AET, because breast cancer is hormone receptor positive in more than 80% of women 65 years and older [40-46], older patients are often precluded from other more toxic forms of systemic treatment such as chemotherapy [47], and the use of AET simplifies managing breast cancer in seniors by eliminating the need for other forms of treatment. Here, NR4A1 is linked to breast cancer.