Expression of SIX family between normal and NSCLC tissues in the representative dataset GSE19188 showed statistical difference (SIX1: p < 0.0001; SIX2: p < 0.0001; SIX3: p = 0.004; SIX4: p < 0.0001; SIX5: p = 0.0027; SIX6: p = 0.0025; Fig. 2g), while the similar tendency was shown in another representative dataset GSE19804 except SIX6 (SIX1: p < 0.0001; SIX2: p < 0.0001; SIX3: p = 0.0146; SIX4: p < 0.0001; SIX5: p = 0.0098; SIX6: p = 0.0615; Fig. 2h). This evidence concerns the gene SIX4 and non-small cell lung carcinoma.