In ADC patients, the expression levels of SIX1-5 were markedly higher than normal in GSE19188 (SIX1: p < 0.0001; SIX2: p < 0.0001; SIX3: p = 0.0129; SIX4: p < 0.0001; SIX5: p = 0.0193; SIX6: p = 0.077; Fig. 3g). The gene discussed is SIX4; the disease is AIDS dementia complex.