However, Mimae T et al. reported that in microdesected tissue, mRNA and protein expressions of SIX1 were elevated in minimally invasive ADC and double upregulation of Notch2 and SIX1 contributed to preinvasive-to-invasive transition in ADC, suggesting that SIX1 contributed to the progression of ADC [16]. This evidence concerns the gene SIX1 and AIDS dementia complex.