Thus, it was reasonable to consider that p38MAPK-1/HIF-1α/HO-1 were highly associated with coronary lesion characteristics and prognosis for peri-menopausal women, providing clues that p38MAPK-1/HIF-1α/HO-1 could act as biomarkers for diagnosis and prognosis of peri-menopausal women suffering from CAD. The gene discussed is HIF1A; the disease is coronary artery disorder.