Expressions of MAPK-1, HIF-1α and HO-1 in the pre-menopausal group were found to over-number those in the non-CAD group (P < 0.05), and the three proteins in the post-menopausal group expressed even higher than those in the pre-menopausal group (P < 0.05) (Table 3). This evidence concerns the gene HIF1A and coronary artery disorder.