Accumulating evidence also confirmed that the hypoxic pre-conditioning (HPC) mechanism mobilized by activated HIF-1α not only eased arrhythmia after ischemia-reperfusion via improving intracellular ion disorder, but also ameliorated blood supply by way of releasing endothelium-derived relaxing factor (EDRF) [33, 34]. The gene discussed is AHSP; the disease is cardiac arrhythmia.