Interestingly, despite groups of non-CAD, pre-menopausal CAD and post-menopausal CAD, expressions of HIF-1α and HO-1 increased significantly with changes of lesion vessels (left main coronary artery < anterior descending artery < circumflex coronary artery < right coronary artery), number of stenosed coronary vessel (single vessel lesion < double vessel lesion < triple vessel lesion) and lesion type (type A < type B < type C)(P < 0.05) (Table 6). The gene discussed is HIF1A; the disease is coronary artery disorder.