Pre-menopausal group and post-menopausal group also exhibited the similar tendencies of the three relations as non-CAD group, which were specifically displayed as: HO-1 and HIF-1(rs = 0.52, P < 0.05; rs = 0.34, P < 0.05), p38MAPK and HIF-1 (rs = 0.28, P < 0.05; rs = 0.20, P < 0.05), p38MAPK and HO-1 (rs = 0.38, P < 0.05; rs = 0.23, P < 0.05) (Figs. 2 and 3). Here, HMOX1 is linked to coronary artery disorder.