ERBB2 and digestive system carcinoma: In the present study, we found a significant association between pattern of Her-2/neu staining & grade of colorectal cancer which is in accordance with one of the study done in the same region but to note here is that they compared the significance of Her-2/neu expression in different grades amongst different types of gastrointestinal carcinomas (gastric, small intestine and colorectal carcinomas) and did not primarily correlate the Her-2/neu expression within different grades of colorectal carcinoma.