In many cases, the 'current BMI' was lower than BMImax, and as a result, the analyses using ‘current BMI’ might underestimate the effects of obesity/adiposity on conferring susceptibility to T2D, and overestimate the genetic effects of FTO variants on T2D risk, producing conflicting results regarding the association of FTO variants with T2D [24]. Here, FTO is linked to obesity due to melanocortin 4 receptor deficiency.