A bioinformatics analysis revealed a strong correlation between TNC mRNA upregulation and expression of hypoxia-induced genes in both WT and R132H IDH1 patient GBMs (Fig. 3a), and expression of carbonic anhydrase 9 (CA9), a HIF1α-target gene, was reduced in R132H tumours (Fig. 3b). This evidence concerns the gene CA9 and neoplasm.