Recent studies, including analyses with CD200R- or CD200-deficient mice, have demonstrated that the CD200-CD200R interaction plays important roles in negatively regulating immune responses, and attenuate autoimmune diseases, excessive inflammatory responses against pathogens, or anti-tumor immunity9, 15, 16, 17, 18, 19, 20. The gene discussed is CD200R1; the disease is autoimmune disease.