In this study, the role of aberrant mTOR activity in the mesenchymal compartment in the pathogenesis of liver fibrosis in a conditional TSC1 knockout mouse model was investigated, which showed that TSC1 deletion in mesenchymal cells aggravated liver fibrosis and was associated with myofibroblast proliferation and apoptosis. The gene discussed is TSC1; the disease is Hepatic fibrosis.