Gain-of-function mutations in the NLRP3 gene (R260W and Q705K) lead to enhanced basal IL-1β production and are linked to Muckle-Well syndrome, familial cold autoinflammatory syndrome and chronic infantile neurologic cutaneous and articular syndrome13, 14, 15, 16. The gene discussed is NLRP3; the disease is familial cold autoinflammatory syndrome.