However, miR-30c has multiple targets including growth factors26, extracellular matrix proteins51, cytokine receptors52, transcription factors, and ADAM family members), and miR-30c is probably mediated by some upstream transcription factors including Spermatogenic leucine zipper protein 1 (Spz1), (sex determining region Y)-box 17 (SOX17), and Hepatocyte Nuclear Factor-3 Homologue 1 (HFH-1) etc., suggesting that additional experiments will be required to further define the upstream and downstream regulatory network of miR-30c on thrombosis formation in DM2 in future studies. The gene discussed is SPZ1; the disease is myotonic dystrophy type 2.