CSF NF-L has also been shown to increase in axonal degenerative disease such as Alzheimer’s disease (AD), multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)8, 34, 35, 36, 37, 38. The gene discussed is NEFL; the disease is amyotrophic lateral sclerosis.