In the present study, we (i) measured IL-17, MVD, IL-6, IL-8 and VEGF expression and examined their associations in human lung adenocarcinoma tissues; (ii) measured MVD, IL-6, IL-8, VEGF and STAT1 expression in A549-IL-17 cell-bearing nude mice; and (iii) determined the effects of a STAT1 inhibitor and siRNA on IL-17-induced IL-6, IL-8 and VEGF expression in A549 and H292 cells in vitro. This evidence concerns the gene CXCL8 and lung adenocarcinoma.