In addition, we have also revealed that IL-6, IL-8, and VEGF are positively associated with MVD by CD31 staining in human adenocarcinoma tissues, consistent with the results of previous studies that demonstrated that IL-630, IL-831 and VEGF32 are associated with angiogenesis in cancer, including NSCLC. The gene discussed is PECAM1; the disease is adenocarcinoma.