Similarly, in isolated hearts with ischemia/reperfusion injury, we also found (Fig. 6A,B) that SOD-2 and thioredoxin were remarkably reduced in the left ventricle of rat hearts subjected to 30 min ischemia followed by 2 h reperfusion (n = 4, P < 0.01 vs. sham group). Here, SOD2 is linked to ischemia.