ATF4 and early-onset autosomal dominant Alzheimer disease: Indeed, while ATF4 is upregulated in the brains of patients with and mouse models of Alzheimer’s Disease, suggesting a correlation between memory dysfunction and increased transcriptional repression, transgenic mice without ATF4 have impaired LTP, LTD, and memory [71], indicating that the relationship between CREB isoforms in mammals may be more complicated.