APOE and Mental deterioration: Additionally, physical activity can affect the apolipoprotein E (APOE) genotypes which were divided as APOEε4 carriers (ε2/ε4, ε3/ε4, and ε4/ε4 genotypes) and noncarriers (ε2/ε2, ε2/ε3, and ε3/ε3 genotypes) because APOE can affect cognitive decline [38].