Jablonowska et al. (2014) suggested that this discrepancy in results could be explained by a genetic variability in SOCS3 since a genetic polymorphism in the SOCS3 gene was reported to influence the level of SOCS3 expression and IFN treatment outcome in chronic hepatitis C (Persico et al. 2008). The gene discussed is IFNA1; the disease is chronic hepatitis C virus infection.