SOCS3 and chronic hepatitis C virus infection: Persico et al. (2008) studied three SOCS3 genetic polymorphisms, 1383 A/G, (rs4969168), −4874 A/G (rs4969170) and −8464 A/C (rs12952093) and reported that these genetic polymorphisms in chronic hepatitis C regulate the expression of SOCS3 and interferon treatment outcome.