MTOR and hepatocellular carcinoma: In 2012 Gomez-Martin and colleagues reported their experience in a descriptive, open, multicenter, retrospective, uncontrolled cohort study designed to assess the combined use of an mTOR inhibitor (Everolimus or Sirolimus) and Sorafenib in the treatment of patients with HCC recurrence after LT (Gomez-Martin et al., 2012).