HMGCS2 and colorectal carcinoma: To examine the direct effects of HMGCS2, we established stable transfectants with HMGCS2 knockdown in CRC cells, including DLD1/shHMGCS2#1 and #2, and OSCC cells, including SAS/shHMGCS2#5 and #8 (Figure 3A, 3B, upper panel).