Considering that the anti-TM4SF5 antibody suppresses tumor growth in HCC and colon cancer models established by subcutaneous cancer cell injection [14, 15], the anti-TM4SF5 antibody might perform a dual anti-cancer function of suppressing the growth of primary tumors, as well as metastasis of the tumors, to other body sites including lung. Here, TM4SF5 is linked to malignant colon neoplasm.