Considering that the anti-TM4SF5 antibody suppresses tumor growth in HCC and colon cancer models established by subcutaneous cancer cell injection [14, 15], the anti-TM4SF5 antibody might perform a dual anti-cancer function of suppressing the growth of primary tumors, as well as metastasis of the tumors, to other body sites including lung. This evidence concerns the gene TM4SF5 and colonic neoplasm.