As shown in Figure 1, the levels of serum periostin were significantly higher in NSCLC patients compared with those in healthy controls (49.46 ± 8.46ng/ml vs. 21.27 ± 3.42ng/ml, P < 0.001), and those in BLD patients (49.46 ± 8.46ng/ml vs. 24.11 ± 4.67ng/ml, P < 0.001). This evidence concerns the gene POSTN and non-small cell lung carcinoma.