Furthermore, knockdown of OCT4 remarkably enhanced apoptosis of PC-9/GR cells received gefitinib in comparision with matched group, suggesting OCT4 contributes to gefitinib resistance in NSCLC cells and that knockdown of OCT4 remarkably enhanced gefitinib-induced apoptosis of PC-9/GR cells. Here, POU5F1 is linked to non-small cell lung carcinoma.