NOTCH1 and kidney disorder: Our previous studies have shown that the renal disease of SIOD is cell autonomous [5, 32]; therefore, we hypothesized that if the increased glomerular levels of unphosphorylated β-catenin and NICD are potentially causative of the renal disease in SIOD, then the levels of unphosphorylated β-catenin and NICD are not increased in renal grafts of SIOD patients.