Interestingly, although FHHt patients with mutations in CUL3, KLHL3 or WNK present the same clinical symptoms, those with mutations in CUL3 have a more severe phenotype, evident in terms of both an earlier age-of-onset and the degree of hypertension and electrolyte disturbance reported [15, 84, 85]. Here, CUL3 is linked to Hypertension.