Although Chen and McCormick [16] demonstrated a similar gene therapy strategy targeting colon cancer by a β-catenin/TCF-response promoter driving the expression of the pro-apoptotic gene Fadd. Beneficial effects have also been observed by inhibition of proliferation of pancreatic and gastric cancer cells using the β-catenin promoter to drive the expression of suicide genes [17,18]. This evidence concerns the gene HNF4A and malignant colon neoplasm.