SCUBE3 function is also associated with other tissues, for example, Scube3 overexpression in transgenic mice induced cardiac hypertrophy (Yang et al. 2007), and zebrafish Scube3 was recently identified as a key regulator of fast muscle development by modulating fibroblast growth factor signaling (Tu et al. 2014). The gene discussed is SCUBE3; the disease is cardiac hypertrophy.