After applying the Bonferroni correction for the number of genes tested, we did not observe any significant findings using either SKAT or the burden test: The smallest p value was 0.004 (SKAT) for overall breast cancer when we included all nonsynonymous rare variants in ORAOV1 on chromosome 11q13 (Table 3, Fig. 3). Here, LTO1 is linked to breast carcinoma.