Only 1 of these 12 differentially methylated CpG sites (cg27461196, mapped to LGI4/FXYD1) was statistically significantly associated with COPD at an FDR of 5 % in an independent, larger WH COPD methylation dataset cleaned and processed in a comparable way. The gene discussed is FXYD1; the disease is chronic obstructive pulmonary disease.