To identify the effector mechanisms by which bradykinin prevents renal insufficiency, we evaluated fungal load and inflammatory cell influx at days 3 and 7 p.i. Although differences in kidney function were already evident early as day 7 p.i. (Fig 4D), fungal loads were comparable between the bradykinin treated and untreated groups at these time points (Fig 5A). The gene discussed is KNG1; the disease is Renal insufficiency.