To understand how IL-17 mediates kidney-specific immunity, we performed Illumina microarray analyses comparing WT and IL-17RA-/- renal gene expression at 48 h p.i. Confirming previous reports, IL-17RA-/- mice demonstrated significantly increased kidney fungal burden in comparison to WT following infection with C. albicans (CAF2-1 or SC5314) (Fig 1A) [14,16,33]. The gene discussed is IL17RA; the disease is infection.