This cohort allows us to analyse a population with PDAC (among the 651 recruits 364 had a diagnosis of PDAC), with the advantage of having: (i) clinical and biochemical data collected according to a standard protocol (prospective design); (ii) diabetes diagnosis based on fasting glucose or glycosylated hemoglobin instead of proxy or self-reported information; (iii) information on insulin secretion and sensitivity and/or islet autoimmunity; and (iv) planned follow-up. Here, INS is linked to diabetes mellitus.