Under HF feeding condition, both male and female BAFF-/- mice showed increased PPARγ activity by preventing its phosphorylation at Ser112, as well as up-regulated expressions of lipogenic and adipogenic genes, such as CD36, C/EBPα, PPARγ, TLE3 and SCD1, compared to their WT counterparts (S3A Fig and S3B Fig) in subcutaneous adipose tissue, showing no male-female difference. The gene discussed is SCD; the disease is hydrops fetalis.