IRS1 and myeloid sarcoma: Alterations in mRNA abundance for GLUT4, IRS1, ACACA, FASN, FATP2, CD36, and G6PC observed in adipose and liver tissues, coupled with elevated insulin and leptin in male offspring, provide further evidence for developmental programming of MS in this model, though as noted previously, exposure may have continued after birth due to placental or lactational transfer.