Although b-AP15 has been examined in murine models of various cancers30 including MM,33 the in vivo activity of its lead optimized analog, VLX1570, has been described in only two disease models thus far.42, 43 Thus, using our murine xenograft model of WM,44 we administered VLX1570 via intraperitoneal injection to WM-bearing mice. This evidence concerns the gene PPIB and Miyoshi myopathy.