In vivo studies of this sort—under defined genetic, environmental and dietary conditions afforded by GEMMs of human cancer—may not only speed up the evaluation of new treatment options for patients with WM,54, 55, 56, 57, 58 but also permit us to close thorny knowledge gaps in our understanding of the natural history of the disease.59 New insights gleaned from integrated analyses of the WM genome60 will guide future approaches to improve on the BCL2+IL6+AID− model. Here, BCL2 is linked to cancer.