We demonstrated that ectopic overexpression of midkine remarkably remedied inhibition of Huh7 cell proliferation, migration, and invasion caused by IGF-1R suppression, suggesting that the reduced midkine expression may contribute, at least in part, to significantly reduced HCC proliferation, migration, and invasion capability induced by IGF-1R suppression. The gene discussed is IGF1R; the disease is hepatocellular carcinoma.