IGF1R and hepatocellular carcinoma: Similar to our results, Tovar et al. showed that A12, a monoclonal antibody against IGF-1R, delayed tumor growth and improved survival in an HCC xenograft model [23]; Lin et al. indicated that suppressing IGF-IR expression by antisense oligonucleotides resulted in significant inhibition of tumor growth, relapse, and metastasis of orthotopic implantation model of human HCC in nude mice [25].