To investigate the role of IGF-1R in HCC, we examined the level of IGF-1R mRNA in HCC cells, and in 29 human HCC tissues, 29 matched adjacent nontumorous tissues (MANT), and 12 normal adult liver tissues (NALT) (obtained from the patients with hepatic hemangioma and hepatic rupture) by quantitative RT-PCR. The gene discussed is IGF1R; the disease is liver hemangioma.