In the current study, we did this the other way around and tested the effects of reconstituted overexpression of WISP-1 in MSC-DFNotch1−/− on melanoma behavior in vitro and in vivo. In general, our results of both knocking-down and overexpressing WISP-1 in the presence of high or low Notch1 activity are consistent. This evidence concerns the gene CCN4 and melanoma.