To further study the tumor-regulating role of MSC-DF carrying high Notch1 activity in melanoma, cell mixtures of MSC-DFN1IC+/+ + Luc2+-C8161 vs. MSC-DFLSL-N1IC + Luc2+-C8161 were co-grafted onto the skin of SCID mice (n = 6/group). The gene discussed is NOTCH1; the disease is neoplasm.