Immunohistochemistry on tissue sections from PRNP codon 129 VV hGH-iCJD patients showed a combination of synaptic, perineuronal and plaque-like deposits of PrP in the cerebral cortex often in a distinctive linear distribution in the deeper cortical layers, a pattern of PrP pathology very similar to that in the VV2 subtype of sporadic CJD (Fig. 5a, i). Here, PRNP is linked to sporadic Creutzfeldt-Jakob disease.