Given the frequency with which molecular abnormalities involving BRAF and other MAP kinase pathway components feature in low-grade epileptogenic brain tumors of childhood [21]—particularly pilocytic astrocytoma, pleomorphic xanthoastrocytoma (PXA), and ganglioglioma—we reasoned that PLNTYs might harbor similar events. This evidence concerns the gene BRAF and pleomorphic xanthoastrocytoma.