In addition to distancing lesions of the PLNTY group from conventional “adult-type” gliomas of the infiltrating variety (a matter of great practical import given that the latter are rarely curable by surgical or adjuvant means, are prone to progression and eventually fatal in the great majority of cases), shared CD34 expression may well reflect a link between PLNTYs and other tumors long recognized for their association with chronic epilepsy in young subjects. This evidence concerns the gene CD34 and central nervous system cancer.