While the demonstration of aberrant CD34 expression by neoplastic and ramified neural elements certainly suggests PLNTY in the appropriate context, calling into serious question the diagnosis of any conventional glioma of infiltrating type, it would be premature to conclude that this finding obviates the need for assessments of IDH1/2 mutation and chromosome 1p/19q codeletion status in the evaluation of neurosurgical specimens. The gene discussed is IDH1; the disease is central nervous system cancer.