In fact, we believe that ostensibly infiltrating glial neoplasms deriving from young individuals (especially those posing as chromosome 1p/19q non-codeleted oligodendrogliomas) should be assessed in similar fashion irrespective of CD34 expression status, as the CD34-labeling tumors we describe may constitute but a subset of fundamentally unified neuroepithelial neoplasms sharing a spectrum of MAPK pathway-activating genetic lesions. This evidence concerns the gene CD34 and glioma.