The major finding of this study is that the PON1 Q192R polymorphism is associated with increased atherogenicity, i.e. the PON1-QR genotype increases the Framingham risk score and the interaction between smoking by PON1-RR carriers is associated with an increased AIP and Framingham score risk and by lowered HDL-cholesterol and increased triglyceride levels. Here, PON1 is linked to autoimmune pancreatitis.