Although it has once believed that ‘cytokine storm’ is the main cause of sepsis, recent studies have proved that septic death can still take place in mice lacking caspase-1 activation and IL-1β production (due to caspase-1 gene deletion but retaining of caspase-11 gene), reinforcing the idea that caspase-11-mediated pyroptosis is critical for septic shock (Kayagaki et al., 2013). This evidence concerns the gene CASP1 and Sepsis.