Mutations in FBN1, a gene located on chromosome 15q21.1 that encodes fibrillin-1, result in the ocular, cardiovascular, osteoarticular (among these: elbows’ contractures; Table 1), pulmonary, skin and central nervous features characteristic of MFS (Loeys et al., 2010; Giusti et al., 2016; Pepe et al., 2016). This evidence concerns the gene FBN1 and Marfan syndrome.