Moreover, no data are reported in literature regarding joint hypermobility and contractures in other fibrillinopathies (ectopia lentis, Shprintzen–Goldberg syndrome, Weill–Marchesani syndrome, familial or isolated aortic aneurysms) caused by alteration of fibrillin-1 and fibrillin-2. This evidence concerns the gene FBN1 and isolated ectopia lentis.