TGFBR1 and Marfan syndrome: Mutations in other genes: TGFB2 (Lindsay et al., 2012), TGFB3 (Matyas et al., 2014), Mothers Against Decapentaplegic, Drosophila, Homolog of 3 (SMAD3; van de Laar et al., 2011), all components of TGF-β signaling, have been found associated to other diseases (LDS1, 2 and 3, respectively) in differential diagnosis with LDS, MFS and other inherited connective tissue disorders.