The knowledge of the interaction between EF and TGF-β signaling confirms the connection demonstrated in humans through mutations in FBN1, TGFBR1 and TGFBR2 genes that are known to cause MFS and overlapping disorder as Loeys-Dietz syndrome (LDS), familiar thoracic aorta aneurysms and dissections (Giusti et al., 2016). The gene discussed is TGFBR1; the disease is Marfan syndrome.