↑ oxy-Hb during threat task for patients compared to healthy adults. BD patients ↑ oxy-Hb in left inferior frontal region, MDD patients ↑ oxy-Hb in left middle frontal region. For happy words BD patients ↓ oxy-Hb in middle and frontal regions, MDD patients no change. Here, GSTM1 is linked to major depressive disorder.