Indeed, our recent work using C57BL/6J mice suggested that IFNAR1-signalling via IRF7 but not IRF3 limited parasite control during PcAS infection [42,43], although other recent work, using a different route of infection [54] or a different genetic background [55] suggested more modest roles for IFN-I-signalling in mice. The gene discussed is IRF7; the disease is infection.