ABCB1 and ovarian carcinoma: Similarly, a whole-genome sequence analysis of a large cohort of sensitive, resistant and refractory ovarian carcinoma tissue specimens performed by Patch et al. revealed that ABCB1 was overexpressed in the recurrent and refractory tumors compared with the sensitive ones, which was caused by recurrent promoter fusion with SLC25A40 and led to acquired resistance to chemotherapy [79].