For example, ZnT-10 mRNA expression is decreased in the frontal cortex of Alzheimer’s disease patients [9], ZIP-4 is dysfunctional in acrodermatitis enteropathica [10,11], and ZnT-8 mutant allele are associated with an increased risk of type 2 diabetes mellitus [12]. This evidence concerns the gene SLC30A10 and early-onset autosomal dominant Alzheimer disease.