IM showed exclusive expression (Camp, Trem1, IL1r2, Ltb4r1, and Mbp) and relative higher expression (Plaur, Spn, Tgfbi, S100a8, S100a9, and Sell) of a diverse set of immune-related genes, which comprised cytokines, membrane proteins and receptors, signal transduction molecules, compared to KC at baseline and during infection (S1 Table). The gene discussed is SPN; the disease is infection.