For example, at day 90, AST value (85.33 ± 2.05U/L) in male rats from GE2 group is significantly reduced compared with AST value (97.00 ± 2.94 U/L) (p <0.05) in male rats from BD group; levels of TP (59.59 ± 0.82g/L), ALB (37.88 ± 0.31 g/L), and ALP (45.67 ± 4.19 U/L) in female rats from GE2 group are significantly higher than corresponding levels (TP = 55.95 ± 1.28 g/L), ALB = 35.51 ± 0.71 g L, ALP = 35.33 ± 2.05 U/L) in female rats from BD group (p <0.05 for all three test results, see Fig 4). This evidence concerns the gene ALB and Behcet disease.