Considering that cellular senescence limits the muscle stem cell regenerative capacity [18], it is reasonable to envisage that the phenotype observed following FXR1 dysfunction in facioscapulohumeral muscular dystrophy could be caused by concomitant overstimulation of cellular senescence, thus leading to muscle tissue degeneration. The gene discussed is FXR1; the disease is facioscapulohumeral muscular dystrophy.