Therefore, multivariate analysis was performed using all HER2 samples (n = 110) to include node status, tumour size and grade, demonstrating that the ImmunoSkew score is independently prognostic in HER2 breast cancer (p = 0.02, HR = 1.51, CI = [1.07, 2.13]; Table 1). This evidence concerns the gene ERBB2 and neoplasm.