PRKN and Parkinson disease: Over the course of the past decades, some genes increase the risk of PD such as α-synuclein (SNCA), parkin (PARK2), PTEN-induced putative kinase 1 (PINK1), oncogene DJ-1 (DJ-1), leucine-rich repeat kinase 2(LRRK2) and ATPase type 13A2 (ATP13A2) have emerged from previous investigations1, 2, 3.