LRRK2 and Parkinson disease: Combined with this meta-analysis study, our findings not only indicated the epidemiological characters of R1628P variant of LRRK2 in ethnic Han-Chinese population, but also elucidated the molecular mechanism underlying genotype-environment interaction-related LRRK2 R1628P variant in neuronal death in LRRK2-linked PD and provide a novel therapeutic target for drug design or genetic modulation.